Serine/threonine-protein phosphatase 4 regulatory subunit 3B (PPP4R3B)
Homo sapiens — UniProt Q5MIZ7
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein phosphatase 4 regulatory subunit 3B (PPP4R3B) is a protein from Homo sapiens identified by UniProt accession Q5MIZ7, 849 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q5MIZ7; gene symbol PPP4R3B.
- Organism: Homo sapiens.
- Length: 849 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, diastolic blood pressure and Vitiligo.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein phosphatase 4 regulatory subunit 3B |
|---|---|
| UniProt accession | Q5MIZ7 |
| Gene | PPP4R3B |
| Organism | Homo sapiens |
| Length | 849 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.33
- diastolic blood pressure · score 0.26
- Vitiligo · score 0.22
- hypothyroidism · score 0.20
- myxedema · score 0.14
- cortical thickness · score 0.11
- Thyroid preparation use measurement · score 0.09
- autoimmune thyroid disease · score 0.09
- MODY · score 0.08
- Antiglaucoma preparations and miotics use measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5MIZ7-F1 | alphafold | PREDICTED | 75.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5MIZ7.
Amino-acid sequence (849 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPP4R3B?
The strongest Open Targets associations for PPP4R3B are systolic blood pressure, diastolic blood pressure, Vitiligo, hypothyroidism and myxedema.
How long is the PPP4R3B protein?
The Homo sapiens PPP4R3B protein (UniProt Q5MIZ7) is 849 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5MIZ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5MIZ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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