Sperm protein associated with the nucleus on the X chromosome N4 (SPANXN4)
Homo sapiens — UniProt Q5MJ08
Data last refreshed: (UniProt release unknown)
Key facts
Sperm protein associated with the nucleus on the X chromosome N4 (SPANXN4) is a protein from Homo sapiens identified by UniProt accession Q5MJ08, 99 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.
- UniProt accession: Q5MJ08; gene symbol SPANXN4.
- Organism: Homo sapiens.
- Length: 99 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, unipolar depression and mood disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm protein associated with the nucleus on the X chromosome N4 |
|---|---|
| UniProt accession | Q5MJ08 |
| Gene | SPANXN4 |
| Organism | Homo sapiens |
| Length | 99 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (5)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- unipolar depression · score 0.03
- mood disorder · score 0.03
- COVID-19 · score 0.01
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5MJ08-F1 | alphafold | PREDICTED | 69.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5MJ08.
Amino-acid sequence (99 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPANXN4?
The strongest Open Targets associations for SPANXN4 are neurodegenerative disease, unipolar depression, mood disorder, COVID-19 and cancer.
How long is the SPANXN4 protein?
The Homo sapiens SPANXN4 protein (UniProt Q5MJ08) is 99 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5MJ08 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5MJ08 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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