F-box only protein 47 (FBXO47)
Homo sapiens — UniProt Q5MNV8
Data last refreshed: (UniProt release unknown)
Key facts
F-box only protein 47 (FBXO47) is a protein from Homo sapiens identified by UniProt accession Q5MNV8, 452 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.
- UniProt accession: Q5MNV8; gene symbol FBXO47.
- Organism: Homo sapiens.
- Length: 452 amino acids.
- Top disease associations (Open Targets): platelet count, platelet crit and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box only protein 47 |
|---|---|
| UniProt accession | Q5MNV8 |
| Gene | FBXO47 |
| Organism | Homo sapiens |
| Length | 452 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (104)
Diseases linked to this target (Open Targets).
- platelet count · score 0.26
- platelet crit · score 0.21
- azoospermia · score 0.10
- partial chromosome Y deletion · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure 73 · score 0.08
- spermatogenic failure 74 · score 0.08
- spermatogenic failure 59 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5MNV8-F1 | alphafold | PREDICTED | 87.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5MNV8.
Amino-acid sequence (452 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXO47?
The strongest Open Targets associations for FBXO47 are platelet count, platelet crit, azoospermia, partial chromosome Y deletion and Male infertility with spermatogenesis disorder due to single gene mutation.
How long is the FBXO47 protein?
The Homo sapiens FBXO47 protein (UniProt Q5MNV8) is 452 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5MNV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5MNV8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.