WD repeat domain phosphoinositide-interacting protein 3 (WDR45B)

About WD repeat domain phosphoinositide-interacting protein 3

WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) is a protein from Homo sapiens identified by UniProt accession Q5MNZ6, 344 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Disease associations (35)

Diseases linked to this target (Open Targets).

• neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures · score 0.70
• autosomal recessive non-syndromic intellectual disability · score 0.37
• genetic disorder · score 0.18
• breast adenocarcinoma · score 0.18
• neutrophil count · score 0.11
• metabolite measurement · score 0.11
• hepatocellular carcinoma · score 0.09
• eosinophil count · score 0.05
• heel bone mineral density · score 0.02
• BMI-adjusted waist-hip ratio · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5MNZ6.

Amino-acid sequence (344 residues)

External references