WD repeat domain phosphoinositide-interacting protein 1 (WIPI1)
Homo sapiens — UniProt Q5MNZ9
Data last refreshed: (UniProt release unknown)
Key facts
WD repeat domain phosphoinositide-interacting protein 1 (WIPI1) is a protein from Homo sapiens identified by UniProt accession Q5MNZ9, 446 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q5MNZ9; gene symbol WIPI1.
- Organism: Homo sapiens.
- Length: 446 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, alkaline phosphatase measurement and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | WD repeat domain phosphoinositide-interacting protein 1 |
|---|---|
| UniProt accession | Q5MNZ9 |
| Gene | WIPI1 |
| Organism | Homo sapiens |
| Length | 446 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.47
- alkaline phosphatase measurement · score 0.43
- reticulocyte count · score 0.42
- mean corpuscular hemoglobin concentration · score 0.42
- creatinine measurement · score 0.41
- vitamin D measurement · score 0.40
- glomerular filtration rate · score 0.40
- reticulocyte measurement · score 0.39
- Immature Reticulocyte Fraction Measurement · score 0.37
- glucose measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5MNZ9-F1 | alphafold | PREDICTED | 77.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5MNZ9.
Amino-acid sequence (446 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WIPI1?
The strongest Open Targets associations for WIPI1 are Red cell distribution width, alkaline phosphatase measurement, reticulocyte count, mean corpuscular hemoglobin concentration and creatinine measurement.
How long is the WIPI1 protein?
The Homo sapiens WIPI1 protein (UniProt Q5MNZ9) is 446 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5MNZ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5MNZ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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