Tetratricopeptide repeat protein 38 (TTC38)
Homo sapiens — UniProt Q5R3I4
Data last refreshed: (UniProt release unknown)
Key facts
Tetratricopeptide repeat protein 38 (TTC38) is a protein from Homo sapiens identified by UniProt accession Q5R3I4, 469 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q5R3I4; gene symbol TTC38.
- Organism: Homo sapiens.
- Length: 469 amino acids.
- Top disease associations (Open Targets): eosinophil count, triglyceride measurement and urinary metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tetratricopeptide repeat protein 38 |
|---|---|
| UniProt accession | Q5R3I4 |
| Gene | TTC38 |
| Organism | Homo sapiens |
| Length | 469 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.15
- triglyceride measurement · score 0.15
- urinary metabolite measurement · score 0.14
- metabolite measurement · score 0.12
- MODY · score 0.11
- low density lipoprotein cholesterol measurement · score 0.10
- type 2 diabetes mellitus · score 0.10
- fat body mass · score 0.09
- type 1 diabetes mellitus · score 0.09
- diabetes mellitus, transient neonatal, 2 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5R3I4-F1 | alphafold | PREDICTED | 96.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5R3I4.
Amino-acid sequence (469 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TTC38?
The strongest Open Targets associations for TTC38 are eosinophil count, triglyceride measurement, urinary metabolite measurement, metabolite measurement and MODY.
How long is the TTC38 protein?
The Homo sapiens TTC38 protein (UniProt Q5R3I4) is 469 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5R3I4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5R3I4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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