Calcium homeostasis modulator protein 6 (CALHM6)
Homo sapiens — UniProt Q5R3K3
Data last refreshed: (UniProt release unknown)
Key facts
Calcium homeostasis modulator protein 6 (CALHM6) is a protein from Homo sapiens identified by UniProt accession Q5R3K3, 315 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q5R3K3; gene symbol CALHM6.
- Organism: Homo sapiens.
- Length: 315 amino acids.
- Top disease associations (Open Targets): ulcerative colitis, nephrotic syndrome and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium homeostasis modulator protein 6 |
|---|---|
| UniProt accession | Q5R3K3 |
| Gene | CALHM6 |
| Organism | Homo sapiens |
| Length | 315 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- ulcerative colitis · score 0.18
- nephrotic syndrome · score 0.18
- blood protein measurement · score 0.17
- spinal stenosis · score 0.17
- sitting height measurement · score 0.13
- forced expiratory volume · score 0.13
- BMI-adjusted hip circumference · score 0.12
- vital capacity · score 0.12
- body height · score 0.11
- infection · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5R3K3-F1 | alphafold | PREDICTED | 84.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5R3K3.
Amino-acid sequence (315 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CALHM6?
The strongest Open Targets associations for CALHM6 are ulcerative colitis, nephrotic syndrome, blood protein measurement, spinal stenosis and sitting height measurement.
How long is the CALHM6 protein?
The Homo sapiens CALHM6 protein (UniProt Q5R3K3) is 315 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5R3K3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5R3K3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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