Exosome complex component MTR3 (EXOSC6)
Homo sapiens — UniProt Q5RKV6
Data last refreshed: (UniProt release unknown)
Key facts
Exosome complex component MTR3 (EXOSC6) is a protein from Homo sapiens identified by UniProt accession Q5RKV6, 272 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q5RKV6; gene symbol EXOSC6.
- Organism: Homo sapiens.
- Length: 272 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, skin aging and skin aging measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exosome complex component MTR3 |
|---|---|
| UniProt accession | Q5RKV6 |
| Gene | EXOSC6 |
| Organism | Homo sapiens |
| Length | 272 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- skin aging · score 0.06
- skin aging measurement · score 0.06
- hip circumference · score 0.05
- body mass index · score 0.05
- body weight · score 0.05
- haptoglobin measurement · score 0.04
- lymphocyte count · score 0.02
- head and neck squamous cell carcinoma · score 0.01
- hepatocellular carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5RKV6-F1 | alphafold | PREDICTED | 80.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5RKV6.
Amino-acid sequence (272 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXOSC6?
The strongest Open Targets associations for EXOSC6 are neurodegenerative disease, skin aging, skin aging measurement, hip circumference and body mass index.
How long is the EXOSC6 protein?
The Homo sapiens EXOSC6 protein (UniProt Q5RKV6) is 272 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5RKV6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5RKV6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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