Protein phosphatase 1L (PPM1L)
Homo sapiens — UniProt Q5SGD2
Data last refreshed: (UniProt release unknown)
Key facts
Protein phosphatase 1L (PPM1L) is a protein from Homo sapiens identified by UniProt accession Q5SGD2, 360 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q5SGD2; gene symbol PPM1L.
- Organism: Homo sapiens.
- Length: 360 amino acids.
- Top disease associations (Open Targets): chronotype measurement, Hashimoto's thyroiditis and hypothyroidism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein phosphatase 1L |
|---|---|
| UniProt accession | Q5SGD2 |
| Gene | PPM1L |
| Organism | Homo sapiens |
| Length | 360 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.23
- Hashimoto's thyroiditis · score 0.22
- hypothyroidism · score 0.20
- blood urea nitrogen measurement · score 0.14
- self reported educational attainment · score 0.09
- MODY · score 0.06
- coronary artery disease, autosomal dominant 2 · score 0.06
- obesity due to melanocortin 4 receptor deficiency · score 0.05
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.05
- metabolic syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5SGD2-F1 | alphafold | PREDICTED | 89.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5SGD2.
Amino-acid sequence (360 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPM1L?
The strongest Open Targets associations for PPM1L are chronotype measurement, Hashimoto's thyroiditis, hypothyroidism, blood urea nitrogen measurement and self reported educational attainment.
How long is the PPM1L protein?
The Homo sapiens PPM1L protein (UniProt Q5SGD2) is 360 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5SGD2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5SGD2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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