Ventral anterior homeobox 1 (VAX1)
Homo sapiens — UniProt Q5SQQ9
Data last refreshed: (UniProt release unknown)
Key facts
Ventral anterior homeobox 1 (VAX1) is a protein from Homo sapiens identified by UniProt accession Q5SQQ9, 334 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.
- UniProt accession: Q5SQQ9; gene symbol VAX1.
- Organism: Homo sapiens.
- Length: 334 amino acids.
- Top disease associations (Open Targets): microphthalmia, cleft lip and Cleft palate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ventral anterior homeobox 1 |
|---|---|
| UniProt accession | Q5SQQ9 |
| Gene | VAX1 |
| Organism | Homo sapiens |
| Length | 334 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (126)
Diseases linked to this target (Open Targets).
- microphthalmia · score 0.59
- cleft lip · score 0.20
- Cleft palate · score 0.09
- age at first birth measurement · score 0.09
- self reported educational attainment · score 0.06
- abortion · score 0.06
- holoprosencephaly · score 0.05
- Familial short QT syndrome · score 0.05
- holoprosencephaly 9 · score 0.05
- coloboma of macula · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5SQQ9-F1 | alphafold | PREDICTED | 63.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5SQQ9.
Amino-acid sequence (334 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VAX1?
The strongest Open Targets associations for VAX1 are microphthalmia, cleft lip, Cleft palate, age at first birth measurement and self reported educational attainment.
How long is the VAX1 protein?
The Homo sapiens VAX1 protein (UniProt Q5SQQ9) is 334 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5SQQ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5SQQ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.