SH2 domain-containing protein 4B (SH2D4B)

About SH2 domain-containing protein 4B

SH2 domain-containing protein 4B (SH2D4B) is a protein from Homo sapiens identified by UniProt accession Q5SQS7, 431 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	SH2 domain-containing protein 4B
UniProt accession	Q5SQS7
Gene	SH2D4B
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

age-related hearing impairment · score 0.32
platelet component distribution width · score 0.28
PHF-tau measurement · score 0.28
serum IgA measurement · score 0.24
lymphocyte count · score 0.23
neurofibrillary tangles measurement · score 0.15
self reported educational attainment · score 0.14
neutrophil count · score 0.13
monocyte count · score 0.12
coronary artery disease · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5SQS7-F1	alphafold	PREDICTED	83.43	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5SQS7.

Amino-acid sequence (431 residues)

MLQQILHDMY IDPELLAELS DVQKHILFYK MREEQLRRWK ERETWEALAQ DEGLRPPKTK RASDKHIQWL LGADGEVWVW IMGEGPGDKP YEEISEELIA ERARLQAQRE AEELWRQKEA EITKKFRDAL ANEKARILAE KWKVEMEDRK AAKVLEERIH EEFKRKEEEE RKRGEEQIRL QEEQRAKELY WTLKQAQLHC QASEKEEREW EEQLRRSKAA DEERSRRAQR ARDEYRHHSL RAIQKGTVAG LSSMFRELGQ SHEQEARLYH HLPDPGLPQP LALPVRTWER PLRPVSRDVI VRWFKEEQLP RRAGFERNTK FIAPWFHGII SREDAEALLE NMTEGAFLVR VSEKIWGYTL SYRLQKGFKH FLVDASGDFY SFLGVDPNRH ATLTDLVDFH KEEIITVSGG ELLQEPCGQR DSPPDYHLLF E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards