Nucleoporin NUP188 (NUP188)
Homo sapiens — UniProt Q5SRE5
Data last refreshed: (UniProt release unknown)
Key facts
Nucleoporin NUP188 (NUP188) is a protein from Homo sapiens identified by UniProt accession Q5SRE5, 1749 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q5SRE5; gene symbol NUP188.
- Organism: Homo sapiens.
- Length: 1749 amino acids.
- Top disease associations (Open Targets): sandestig-stefanova syndrome, HIV infection and influenza.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleoporin NUP188 |
|---|---|
| UniProt accession | Q5SRE5 |
| Gene | NUP188 |
| Organism | Homo sapiens |
| Length | 1749 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- sandestig-stefanova syndrome · score 0.70
- HIV infection · score 0.54
- influenza · score 0.54
- viral disease · score 0.53
- COVID-19 · score 0.37
- Histiocytosis · score 0.37
- Microcephaly · score 0.33
- neurodegenerative disease · score 0.27
- lysosomal storage disease · score 0.27
- Alzheimer disease · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5SRE5-F1 | alphafold | PREDICTED | 81.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5SRE5.
Amino-acid sequence (1749 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUP188?
The strongest Open Targets associations for NUP188 are sandestig-stefanova syndrome, HIV infection, influenza, viral disease and COVID-19.
How long is the NUP188 protein?
The Homo sapiens NUP188 protein (UniProt Q5SRE5) is 1749 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5SRE5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5SRE5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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