Pleckstrin homology domain-containing family S member 1 (PLEKHS1)
Homo sapiens — UniProt Q5SXH7
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family S member 1 (PLEKHS1) is a protein from Homo sapiens identified by UniProt accession Q5SXH7, 465 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q5SXH7; gene symbol PLEKHS1.
- Organism: Homo sapiens.
- Length: 465 amino acids.
- Top disease associations (Open Targets): mathematical ability, neoplasm and papillary thyroid carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family S member 1 |
|---|---|
| UniProt accession | Q5SXH7 |
| Gene | PLEKHS1 |
| Organism | Homo sapiens |
| Length | 465 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.31
- neoplasm · score 0.08
- papillary thyroid carcinoma · score 0.08
- Vitiligo · score 0.07
- Barrett's esophagus · score 0.07
- esophageal adenocarcinoma · score 0.05
- hematocrit · score 0.05
- Ehlers-Danlos syndrome, musculocontractural type · score 0.05
- cataract · score 0.05
- Age-related cataract · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5SXH7-F1 | alphafold | PREDICTED | 58.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5SXH7.
Amino-acid sequence (465 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHS1?
The strongest Open Targets associations for PLEKHS1 are mathematical ability, neoplasm, papillary thyroid carcinoma, Vitiligo and Barrett's esophagus.
How long is the PLEKHS1 protein?
The Homo sapiens PLEKHS1 protein (UniProt Q5SXH7) is 465 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5SXH7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5SXH7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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