snRNA-activating protein complex subunit 4 (SNAPC4)

Homo sapiens — UniProt Q5SXM2

Gene: SNAPC4Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

snRNA-activating protein complex subunit 4 (SNAPC4) is a protein from Homo sapiens identified by UniProt accession Q5SXM2, 1469 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

UniProt accession: Q5SXM2; gene symbol SNAPC4.
Organism: Homo sapiens.
Length: 1469 amino acids.
Top disease associations (Open Targets): neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction, neurodegenerative disease and ulcerative colitis.
3D structure: AlphaFold model available.

Target properties

Protein name	snRNA-activating protein complex subunit 4
UniProt accession	Q5SXM2
Gene	SNAPC4
Organism	Homo sapiens
Length	1469 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (96)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction · score 0.61
neurodegenerative disease · score 0.44
ulcerative colitis · score 0.22
genetic disorder · score 0.19
C-reactive protein measurement · score 0.19
Crohn's disease · score 0.19
rheumatoid arthritis · score 0.17
vital capacity · score 0.16
ankylosing spondylitis · score 0.16
psoriasis · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5SXM2-F1	alphafold	PREDICTED	51.64	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5SXM2.

Amino-acid sequence (1469 residues)

MDVDAEREKI TQEIKELERI LDPGSSGSHV EISESSLESD SEADSLPSED LDPADPPISE EERWGEASND EDDPKDKTLP EDPETCLQLN MVYQEVIQEK LAEANLLLAQ NREQQEELMR DLAGSKGTKV KDGKSLPPST YMGHFMKPYF KDKVTGVGPP ANEDTREKAA QGIKAFEELL VTKWKNWEKA LLRKSVVSDR LQRLLQPKLL KLEYLHQKQS KVSSELERQA LEKQGREAEK EIQDINQLPE EALLGNRLDS HDWEKISNIN FEGSRSAEEI RKFWQNSEHP SINKQEWSRE EEERLQAIAA AHGHLEWQKI AEELGTSRSA FQCLQKFQQH NKALKRKEWT EEEDRMLTQL VQEMRVGSHI PYRRIVYYME GRDSMQLIYR WTKSLDPGLK KGYWAPEEDA KLLQAVAKYG EQDWFKIREE VPGRSDAQCR DRYLRRLHFS LKKGRWNLKE EEQLIELIEK YGVGHWAKIA SELPHRSGSQ CLSKWKIMMG KKQGLRRRRR RARHSVRWSS TSSSGSSSGS SGGSSSSSSS SSEEDEPEQA QAGEGDRALL SPQYMVPDMD LWVPARQSTS QPWRGGAGAW LGGPAASLSP PKGSSASQGG SKEASTTAAA PGEETSPVQV PARAHGPVPR SAQASHSADT RPAGAEKQAL EGGRRLLTVP VETVLRVLRA NTAARSCTQK EQLRQPPLPT SSPGVSSGDS VARSHVQWLR HRATQSGQRR WRHALHRRLL NRRLLLAVTP WVGDVVVPCT QASQRPAVVQ TQADGLREQL QQARLASTPV FTLFTQLFHI DTAGCLEVVR ERKALPPRLP QAGARDPPVH LLQASSSAQS TPGHLFPNVP AQEASKSASH KGSRRLASSR VERTLPQASL LASTGPRPKP KTVSELLQEK RLQEARAREA TRGPVVLPSQ LLVSSSVILQ PPLPHTPHGR PAPGPTVLNV PLSGPGAPAA AKPGTSGSWQ EAGTSAKDKR LSTMQALPLA PVFSEAEGTA PAASQAPALG PGQISVSCPE SGLGQSQAPA ASRKQGLPEA PPFLPAAPSP TPLPVQPLSL THIGGPHVAT SVPLPVTWVL TAQGLLPVPV PAVVSLPRPA GTPGPAGLLA TLLPPLTETR AAQGPRAPAL SSSWQPPANM NREPEPSCRT DTPAPPTHAL SQSPAEADGS VAFVPGEAQV AREIPEPRTS SHADPPEAEP PWSGRLPAFG GVIPATEPRG TPGSPSGTQE PRGPLGLEKL PLRQPGPEKG ALDLEKPPLP QPGPEKGALD LGLLSQEGEA ATQQWLGGQR GVRVPLLGSR LPYQPPALCS LRALSGLLLH KKALEHKATS LVVGGEAERP AGALQASLGL VRGQLQDNPA YLLLRARFLA AFTLPALLAT LAPQGVRTTL SVPSRVGSES EDEDLLSELE LADRDGQPGC TTATCPIQGA PDSGKCSASS CLDTSNDPDD LDVLRTRHAR HTRKRRRLV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with SNAPC4?

The strongest Open Targets associations for SNAPC4 are neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction, neurodegenerative disease, ulcerative colitis, genetic disorder and C-reactive protein measurement.

How long is the SNAPC4 protein?

The Homo sapiens SNAPC4 protein (UniProt Q5SXM2) is 1469 amino acids long.

Browse: Targets: S · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q5SXM2 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q5SXM2 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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