Low-density lipoprotein receptor class A…

About Low-density lipoprotein receptor class A domain-containing protein 2

Low-density lipoprotein receptor class A domain-containing protein 2 (LDLRAD2) is a protein from Homo sapiens identified by UniProt accession Q5SZI1, 272 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Low-density lipoprotein receptor class A domain-containing protein 2
UniProt accession	Q5SZI1
Gene	LDLRAD2
Organism	Homo sapiens
Length	272 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

Schwartz-Jampel syndrome · score 0.46
Dyssegmental dysplasia, Silverman-Handmaker type · score 0.41
alkaline phosphatase measurement · score 0.26
genetic disorder · score 0.19
connective tissue disease · score 0.15
Microcephaly · score 0.11
von Willebrand factor measurement · score 0.08
Immature Reticulocyte Fraction Measurement · score 0.08
gonorrhea · score 0.07
gastric carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5SZI1-F1	alphafold	PREDICTED	78.73	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5SZI1.

Amino-acid sequence (272 residues)

MEACCLLQLP QRLLLLGAAA LTATALETAD LAELCGQTWQ GDGLLLRSHA ASRRFYFVAP DTDCGLWVQA AAPGDRIRFQ FRFFLVYSLT PAPPALNTSS PAPADPCAPG SYLQFYEGPP GAPRPLGSPL CGLNIPVPVA SSGPFLGLRL VTRGRQPRVD FVGEVTSFRL GPCGAYFRCQ NGRCIPSSLV CDPWGMDNCG DGSDQGSWSP ADCRGPSPVP SQTGSTDAHT SRSLTPSPAL GSAGSLWIAA ERSSPAGRDP TRQDAALEGS TE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Low-density lipoprotein receptor class A domain-containing protein 2 (LDLRAD2)