Low-density lipoprotein receptor class A domain-containing protein 2 (LDLRAD2)
Homo sapiens — UniProt Q5SZI1
Data last refreshed: (UniProt release unknown)
Key facts
Low-density lipoprotein receptor class A domain-containing protein 2 (LDLRAD2) is a protein from Homo sapiens identified by UniProt accession Q5SZI1, 272 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q5SZI1; gene symbol LDLRAD2.
- Organism: Homo sapiens.
- Length: 272 amino acids.
- Top disease associations (Open Targets): Schwartz-Jampel syndrome, Dyssegmental dysplasia, Silverman-Handmaker type and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Low-density lipoprotein receptor class A domain-containing protein 2 |
|---|---|
| UniProt accession | Q5SZI1 |
| Gene | LDLRAD2 |
| Organism | Homo sapiens |
| Length | 272 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- Schwartz-Jampel syndrome · score 0.46
- Dyssegmental dysplasia, Silverman-Handmaker type · score 0.41
- alkaline phosphatase measurement · score 0.26
- genetic disorder · score 0.19
- connective tissue disease · score 0.15
- Microcephaly · score 0.11
- von Willebrand factor measurement · score 0.08
- Immature Reticulocyte Fraction Measurement · score 0.08
- gonorrhea · score 0.07
- gastric carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5SZI1-F1 | alphafold | PREDICTED | 78.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5SZI1.
Amino-acid sequence (272 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LDLRAD2?
The strongest Open Targets associations for LDLRAD2 are Schwartz-Jampel syndrome, Dyssegmental dysplasia, Silverman-Handmaker type, alkaline phosphatase measurement, genetic disorder and connective tissue disease.
How long is the LDLRAD2 protein?
The Homo sapiens LDLRAD2 protein (UniProt Q5SZI1) is 272 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5SZI1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5SZI1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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