Putative hydroxypyruvate isomerase (HYI)

About Putative hydroxypyruvate isomerase

Putative hydroxypyruvate isomerase (HYI) is a protein from Homo sapiens identified by UniProt accession Q5T013, 277 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Putative hydroxypyruvate isomerase
UniProt accession	Q5T013
Gene	HYI
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
diastolic blood pressure · score 0.25
systolic blood pressure · score 0.20
body height · score 0.19
developmental and epileptic encephalopathy · score 0.15
developmental and epileptic encephalopathy, 18 · score 0.15
cognitive function measurement · score 0.14
hemoglobin measurement · score 0.12
mean arterial pressure · score 0.10
attention deficit hyperactivity disorder · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T013-F1	alphafold	PREDICTED	96.30	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T013.

Amino-acid sequence (277 residues)

MAPLRFSANL SWLFPELSGL PARVRAAGSS GFEAVEVAWP YAETPEALAR AAREAGLRLV LINTPPGDQE KGEMGLGAVP GRQAAFREGL EQAVRYAKAL GCPRIHLMAG RVPQGADRIA VKAEMEAVFL ENLRHAAGVL AQEDLVGLLE PINTRITDPQ YFLDTPQQAA AILQKVGRPN LQLQMDIFHW QIMDGNLTGN IREFLPIVGH VQVAQVPGRG EPSSPGELNF PYLFQLLEDE GYKGFVGCEY QPRGDTVEGL SWLRSYWDRR GHPEAGQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards