Tumor protein p63-regulated gene 1-like protein (TPRG1L)
Homo sapiens — UniProt Q5T0D9
Data last refreshed: (UniProt release unknown)
Key facts
Tumor protein p63-regulated gene 1-like protein (TPRG1L) is a protein from Homo sapiens identified by UniProt accession Q5T0D9, 272 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q5T0D9; gene symbol TPRG1L.
- Organism: Homo sapiens.
- Length: 272 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, atypical teratoid rhabdoid tumor and oligodendroglioma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tumor protein p63-regulated gene 1-like protein |
|---|---|
| UniProt accession | Q5T0D9 |
| Gene | TPRG1L |
| Organism | Homo sapiens |
| Length | 272 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.02
- atypical teratoid rhabdoid tumor · score 0.02
- oligodendroglioma · score 0.01
- large cell medulloblastoma · score 0.01
- anxiety · score 0.01
- astrocytoma · score 0.01
- Alzheimer disease · score 0.01
- primitive neuroectodermal tumor · score 0.01
- multiple sclerosis · score 0.01
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T0D9-F1 | alphafold | PREDICTED | 70.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T0D9.
Amino-acid sequence (272 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TPRG1L?
The strongest Open Targets associations for TPRG1L are glioblastoma multiforme, atypical teratoid rhabdoid tumor, oligodendroglioma, large cell medulloblastoma and anxiety.
How long is the TPRG1L protein?
The Homo sapiens TPRG1L protein (UniProt Q5T0D9) is 272 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T0D9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T0D9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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