Spermatogenesis-associated protein 46 (SPATA46)
Homo sapiens — UniProt Q5T0L3
Data last refreshed: (UniProt release unknown)
Key facts
Spermatogenesis-associated protein 46 (SPATA46) is a protein from Homo sapiens identified by UniProt accession Q5T0L3, 261 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.
- UniProt accession: Q5T0L3; gene symbol SPATA46.
- Organism: Homo sapiens.
- Length: 261 amino acids.
- Top disease associations (Open Targets): azoospermia, monocyte count and monocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spermatogenesis-associated protein 46 |
|---|---|
| UniProt accession | Q5T0L3 |
| Gene | SPATA46 |
| Organism | Homo sapiens |
| Length | 261 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (105)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- monocyte count · score 0.10
- monocyte percentage of leukocytes · score 0.10
- electrocardiography · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- QT interval · score 0.08
- longitudinal BMI measurement · score 0.08
- mean reticulocyte volume · score 0.08
- granulocyte percentage of myeloid white cells · score 0.07
- partial chromosome Y deletion · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T0L3-F1 | alphafold | PREDICTED | 55.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T0L3.
Amino-acid sequence (261 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPATA46?
The strongest Open Targets associations for SPATA46 are azoospermia, monocyte count, monocyte percentage of leukocytes, electrocardiography and male infertility with teratozoospermia due to single gene mutation.
How long is the SPATA46 protein?
The Homo sapiens SPATA46 protein (UniProt Q5T0L3) is 261 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T0L3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T0L3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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