Cilia- and flagella-associated protein 70 (CFAP70)
Homo sapiens — UniProt Q5T0N1
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 70 (CFAP70) is a protein from Homo sapiens identified by UniProt accession Q5T0N1, 1121 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.
- UniProt accession: Q5T0N1; gene symbol CFAP70.
- Organism: Homo sapiens.
- Length: 1121 amino acids.
- Top disease associations (Open Targets): spermatogenic failure 41, non-syndromic male infertility due to sperm motility disorder and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 70 |
|---|---|
| UniProt accession | Q5T0N1 |
| Gene | CFAP70 |
| Organism | Homo sapiens |
| Length | 1121 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (119)
Diseases linked to this target (Open Targets).
- spermatogenic failure 41 · score 0.46
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- PHF-tau measurement · score 0.11
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- spermatogenic failure 65 · score 0.08
- spermatogenic failure 56 · score 0.08
- spermatogenic failure 11 · score 0.08
- spermatogenic failure 10 · score 0.08
- spermatogenic failure, X-linked, 3 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T0N1-F1 | alphafold | PREDICTED | 75.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T0N1.
Amino-acid sequence (1121 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP70?
The strongest Open Targets associations for CFAP70 are spermatogenic failure 41, non-syndromic male infertility due to sperm motility disorder, PHF-tau measurement, azoospermia and male infertility with teratozoospermia due to single gene mutation.
How long is the CFAP70 protein?
The Homo sapiens CFAP70 protein (UniProt Q5T0N1) is 1121 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T0N1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T0N1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.