E3 ubiquitin-protein ligase MARCHF8 (MARCHF8)
Homo sapiens — UniProt Q5T0T0
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase MARCHF8 (MARCHF8) is a protein from Homo sapiens identified by UniProt accession Q5T0T0, 291 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q5T0T0; gene symbol MARCHF8.
- Organism: Homo sapiens.
- Length: 291 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, mean corpuscular volume and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase MARCHF8 |
|---|---|
| UniProt accession | Q5T0T0 |
| Gene | MARCHF8 |
| Organism | Homo sapiens |
| Length | 291 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.50
- mean corpuscular volume · score 0.50
- reticulocyte count · score 0.48
- Red cell distribution width · score 0.48
- mean corpuscular hemoglobin · score 0.47
- total cholesterol measurement · score 0.46
- erythrocyte count · score 0.46
- mean corpuscular hemoglobin concentration · score 0.44
- cholelithiasis · score 0.44
- Immature Reticulocyte Fraction Measurement · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T0T0-F1 | alphafold | PREDICTED | 70.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T0T0.
Amino-acid sequence (291 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MARCHF8?
The strongest Open Targets associations for MARCHF8 are high density lipoprotein cholesterol measurement, mean corpuscular volume, reticulocyte count, Red cell distribution width and mean corpuscular hemoglobin.
How long is the MARCHF8 protein?
The Homo sapiens MARCHF8 protein (UniProt Q5T0T0) is 291 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T0T0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T0T0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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