Probable arginine--tRNA ligase, mitochondrial (RARS2)
Homo sapiens — UniProt Q5T160
Data last refreshed: (UniProt release unknown)
Key facts
Probable arginine--tRNA ligase, mitochondrial (RARS2) is a protein from Homo sapiens identified by UniProt accession Q5T160, 578 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q5T160; gene symbol RARS2.
- Organism: Homo sapiens.
- Length: 578 amino acids.
- Top disease associations (Open Targets): pontocerebellar hypoplasia type 6, pontocerebellar hypoplasia and Non-syndromic pontocerebellar hypoplasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable arginine--tRNA ligase, mitochondrial |
|---|---|
| UniProt accession | Q5T160 |
| Gene | RARS2 |
| Organism | Homo sapiens |
| Length | 578 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 6 · score 0.82
- pontocerebellar hypoplasia · score 0.67
- Non-syndromic pontocerebellar hypoplasia · score 0.52
- genetic disorder · score 0.51
- epilepsy · score 0.50
- mitochondrial disease · score 0.37
- isolated cerebellar hypoplasia/agenesis · score 0.32
- self reported educational attainment · score 0.32
- neurodegenerative disease · score 0.27
- Abnormal brain morphology · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T160-F1 | alphafold | PREDICTED | 89.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T160.
Amino-acid sequence (578 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RARS2?
The strongest Open Targets associations for RARS2 are pontocerebellar hypoplasia type 6, pontocerebellar hypoplasia, Non-syndromic pontocerebellar hypoplasia, genetic disorder and epilepsy.
How long is the RARS2 protein?
The Homo sapiens RARS2 protein (UniProt Q5T160) is 578 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T160 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T160 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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