E3 ubiquitin-protein ligase DCST1 (DCST1)
Homo sapiens — UniProt Q5T197
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase DCST1 (DCST1) is a protein from Homo sapiens identified by UniProt accession Q5T197, 706 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.
- UniProt accession: Q5T197; gene symbol DCST1.
- Organism: Homo sapiens.
- Length: 706 amino acids.
- Top disease associations (Open Targets): body height, cystatin C measurement and skin neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase DCST1 |
|---|---|
| UniProt accession | Q5T197 |
| Gene | DCST1 |
| Organism | Homo sapiens |
| Length | 706 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (137)
Diseases linked to this target (Open Targets).
- body height · score 0.33
- cystatin C measurement · score 0.24
- skin neoplasm · score 0.22
- sitting height measurement · score 0.22
- forced expiratory volume · score 0.22
- eosinophil count · score 0.15
- birth weight · score 0.14
- skin cancer · score 0.14
- genetic disorder · score 0.12
- non-melanoma skin carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T197-F1 | alphafold | PREDICTED | 80.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T197.
Amino-acid sequence (706 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCST1?
The strongest Open Targets associations for DCST1 are body height, cystatin C measurement, skin neoplasm, sitting height measurement and forced expiratory volume.
How long is the DCST1 protein?
The Homo sapiens DCST1 protein (UniProt Q5T197) is 706 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T197 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T197 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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