Axonemal dynein light chain domain-containing protein 1 (AXDND1)
Homo sapiens — UniProt Q5T1B0
Data last refreshed: (UniProt release unknown)
Key facts
Axonemal dynein light chain domain-containing protein 1 (AXDND1) is a protein from Homo sapiens identified by UniProt accession Q5T1B0, 1012 residues long. MolForge cross-references it against 0 known binders and 131 disease associations.
- UniProt accession: Q5T1B0; gene symbol AXDND1.
- Organism: Homo sapiens.
- Length: 1012 amino acids.
- Top disease associations (Open Targets): nephrotic syndrome, familial idiopathic steroid-resistant nephrotic syndrome and steroid-resistant nephrotic syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Axonemal dynein light chain domain-containing protein 1 |
|---|---|
| UniProt accession | Q5T1B0 |
| Gene | AXDND1 |
| Organism | Homo sapiens |
| Length | 1012 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (131)
Diseases linked to this target (Open Targets).
- nephrotic syndrome · score 0.57
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.57
- steroid-resistant nephrotic syndrome · score 0.51
- idiopathic nephrotic syndrome · score 0.45
- genetic disorder · score 0.44
- focal segmental glomerulosclerosis · score 0.37
- chronotype measurement · score 0.37
- body height · score 0.33
- azoospermia · score 0.29
- insulin like growth factor measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T1B0-F1 | alphafold | PREDICTED | 70.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T1B0.
Amino-acid sequence (1012 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AXDND1?
The strongest Open Targets associations for AXDND1 are nephrotic syndrome, familial idiopathic steroid-resistant nephrotic syndrome, steroid-resistant nephrotic syndrome, idiopathic nephrotic syndrome and genetic disorder.
How long is the AXDND1 protein?
The Homo sapiens AXDND1 protein (UniProt Q5T1B0) is 1012 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T1B0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T1B0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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