Acyl-coenzyme A thioesterase THEM4 (THEM4)
Homo sapiens — UniProt Q5T1C6
Data last refreshed: (UniProt release unknown)
Key facts
Acyl-coenzyme A thioesterase THEM4 (THEM4) is a protein from Homo sapiens identified by UniProt accession Q5T1C6, 240 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q5T1C6; gene symbol THEM4.
- Organism: Homo sapiens.
- Length: 240 amino acids.
- Top disease associations (Open Targets): serum metabolite measurement, blood metabolite measurement and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acyl-coenzyme A thioesterase THEM4 |
|---|---|
| UniProt accession | Q5T1C6 |
| Gene | THEM4 |
| Organism | Homo sapiens |
| Length | 240 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- serum metabolite measurement · score 0.35
- blood metabolite measurement · score 0.28
- head and neck squamous cell carcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- eye movement measurement · score 0.16
- hair morphology · score 0.15
- acylcarnitine measurement · score 0.09
- triple-negative breast cancer · score 0.08
- cardiac hypertrophy · score 0.07
- urinary metabolite measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T1C6-F1 | alphafold | PREDICTED | 83.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T1C6.
Amino-acid sequence (240 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THEM4?
The strongest Open Targets associations for THEM4 are serum metabolite measurement, blood metabolite measurement, head and neck squamous cell carcinoma, lung adenocarcinoma and eye movement measurement.
How long is the THEM4 protein?
The Homo sapiens THEM4 protein (UniProt Q5T1C6) is 240 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T1C6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T1C6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.