FK506-binding protein 15 (FKBP15)
Homo sapiens — UniProt Q5T1M5
Data last refreshed: (UniProt release unknown)
Key facts
FK506-binding protein 15 (FKBP15) is a protein from Homo sapiens identified by UniProt accession Q5T1M5, 1219 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q5T1M5; gene symbol FKBP15.
- Organism: Homo sapiens.
- Length: 1219 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Wiskott-Aldrich syndrome and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FK506-binding protein 15 |
|---|---|
| UniProt accession | Q5T1M5 |
| Gene | FKBP15 |
| Organism | Homo sapiens |
| Length | 1219 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- Wiskott-Aldrich syndrome · score 0.37
- mean corpuscular volume · score 0.30
- mean corpuscular hemoglobin concentration · score 0.24
- mean reticulocyte volume · score 0.24
- genetic disorder · score 0.15
- neutrophil count · score 0.10
- sum of neutrophil and eosinophil counts · score 0.10
- sum of basophil and neutrophil counts · score 0.08
- granulocyte count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T1M5-F1 | alphafold | PREDICTED | 63.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T1M5.
Amino-acid sequence (1219 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FKBP15?
The strongest Open Targets associations for FKBP15 are neurodegenerative disease, Wiskott-Aldrich syndrome, mean corpuscular volume, mean corpuscular hemoglobin concentration and mean reticulocyte volume.
How long is the FKBP15 protein?
The Homo sapiens FKBP15 protein (UniProt Q5T1M5) is 1219 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T1M5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T1M5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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