Probable ATP-dependent RNA helicase DDX59 (DDX59)
Homo sapiens — UniProt Q5T1V6
Data last refreshed: (UniProt release unknown)
Key facts
Probable ATP-dependent RNA helicase DDX59 (DDX59) is a protein from Homo sapiens identified by UniProt accession Q5T1V6, 619 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q5T1V6; gene symbol DDX59.
- Organism: Homo sapiens.
- Length: 619 amino acids.
- Top disease associations (Open Targets): orofaciodigital syndrome V, Orofaciodigital syndrome type 5 and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX59 |
|---|---|
| UniProt accession | Q5T1V6 |
| Gene | DDX59 |
| Organism | Homo sapiens |
| Length | 619 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- orofaciodigital syndrome V · score 0.75
- Orofaciodigital syndrome type 5 · score 0.62
- neurodegenerative disease · score 0.49
- Joubert syndrome with orofaciodigital defect · score 0.49
- orofaciodigital syndrome · score 0.46
- Polydactyly · score 0.37
- polydactyly · score 0.37
- gut microbiome measurement · score 0.19
- genetic disorder · score 0.19
- coronary artery disease · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T1V6-F1 | alphafold | PREDICTED | 77.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T1V6.
Amino-acid sequence (619 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDX59?
The strongest Open Targets associations for DDX59 are orofaciodigital syndrome V, Orofaciodigital syndrome type 5, neurodegenerative disease, Joubert syndrome with orofaciodigital defect and orofaciodigital syndrome.
How long is the DDX59 protein?
The Homo sapiens DDX59 protein (UniProt Q5T1V6) is 619 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T1V6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T1V6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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