Aldo-keto reductase family 1 member C8 (AKR1C8)
Homo sapiens — UniProt Q5T2L2
Data last refreshed: (UniProt release unknown)
Key facts
Aldo-keto reductase family 1 member C8 (AKR1C8) is a protein from Homo sapiens identified by UniProt accession Q5T2L2, 326 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q5T2L2; gene symbol AKR1C8.
- Organism: Homo sapiens.
- Length: 326 amino acids.
- Top disease associations (Open Targets): triglyceride measurement, sleep duration and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Aldo-keto reductase family 1 member C8 |
|---|---|
| UniProt accession | Q5T2L2 |
| Gene | AKR1C8 |
| Organism | Homo sapiens |
| Length | 326 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.21
- sleep duration · score 0.20
- PHF-tau measurement · score 0.10
- venous thromboembolism · score 0.09
- sex hormone-binding globulin measurement · score 0.07
- metabolite measurement · score 0.06
- testosterone measurement · score 0.05
- insulin like growth factor measurement · score 0.05
- blood protein measurement · score 0.04
- body weight · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T2L2-F1 | alphafold | PREDICTED | 95.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T2L2.
Amino-acid sequence (326 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AKR1C8?
The strongest Open Targets associations for AKR1C8 are triglyceride measurement, sleep duration, PHF-tau measurement, venous thromboembolism and sex hormone-binding globulin measurement.
How long is the AKR1C8 protein?
The Homo sapiens AKR1C8 protein (UniProt Q5T2L2) is 326 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T2L2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T2L2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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