ATPase family AAA domain-containing protein 3C (ATAD3C)
Homo sapiens — UniProt Q5T2N8
Data last refreshed: (UniProt release unknown)
Key facts
ATPase family AAA domain-containing protein 3C (ATAD3C) is a protein from Homo sapiens identified by UniProt accession Q5T2N8, 411 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q5T2N8; gene symbol ATAD3C.
- Organism: Homo sapiens.
- Length: 411 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hip bone size and hypertriglyceridemia 2.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATPase family AAA domain-containing protein 3C |
|---|---|
| UniProt accession | Q5T2N8 |
| Gene | ATAD3C |
| Organism | Homo sapiens |
| Length | 411 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- hip bone size · score 0.07
- hypertriglyceridemia 2 · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.05
- hip bone mineral density · score 0.05
- pancreatic triacylglycerol lipase deficiency · score 0.05
- Combined hyperlipidemia · score 0.04
- thyroid hormone metabolism, abnormal, 2 · score 0.04
- sitosterolemia · score 0.04
- homozygous familial hypercholesterolemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T2N8-F1 | alphafold | PREDICTED | 83.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T2N8.
Amino-acid sequence (411 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATAD3C?
The strongest Open Targets associations for ATAD3C are neurodegenerative disease, hip bone size, hypertriglyceridemia 2, cholesterol-ester transfer protein deficiency and hip bone mineral density.
How long is the ATAD3C protein?
The Homo sapiens ATAD3C protein (UniProt Q5T2N8) is 411 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T2N8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T2N8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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