Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)
Homo sapiens — UniProt Q5T2W1
Data last refreshed: (UniProt release unknown)
Key facts
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) is a protein from Homo sapiens identified by UniProt accession Q5T2W1, 519 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q5T2W1; gene symbol PDZK1.
- Organism: Homo sapiens.
- Length: 519 amino acids.
- Top disease associations (Open Targets): urate measurement, uric acid measurement and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 |
|---|---|
| UniProt accession | Q5T2W1 |
| Gene | PDZK1 |
| Organism | Homo sapiens |
| Length | 519 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.64
- uric acid measurement · score 0.28
- neurodegenerative disease · score 0.27
- contrast sensitivity measurement · score 0.21
- gout · score 0.19
- drug use measurement · score 0.14
- hepatocellular carcinoma · score 0.09
- neoplasm · score 0.08
- nonpapillary renal cell carcinoma · score 0.08
- hypertriglyceridemia 2 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T2W1-F1 | alphafold | PREDICTED | 78.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T2W1.
Amino-acid sequence (519 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PDZK1?
The strongest Open Targets associations for PDZK1 are urate measurement, uric acid measurement, neurodegenerative disease, contrast sensitivity measurement and gout.
How long is the PDZK1 protein?
The Homo sapiens PDZK1 protein (UniProt Q5T2W1) is 519 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T2W1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T2W1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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