Mechanosensitive cation channel TMEM63B (TMEM63B)
Homo sapiens — UniProt Q5T3F8
Data last refreshed: (UniProt release unknown)
Key facts
Mechanosensitive cation channel TMEM63B (TMEM63B) is a protein from Homo sapiens identified by UniProt accession Q5T3F8, 832 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.
- UniProt accession: Q5T3F8; gene symbol TMEM63B.
- Organism: Homo sapiens.
- Length: 832 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): developmental and epileptic encephalopathy, neurodegenerative disease and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mechanosensitive cation channel TMEM63B |
|---|---|
| UniProt accession | Q5T3F8 |
| Gene | TMEM63B |
| Organism | Homo sapiens |
| Length | 832 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy · score 0.46
- neurodegenerative disease · score 0.27
- Red cell distribution width · score 0.19
- mean platelet volume · score 0.19
- genetic disorder · score 0.19
- vascular endothelial growth factor measurement · score 0.18
- hemoglobin measurement · score 0.16
- interleukin 12 measurement · score 0.16
- interleukin 10 measurement · score 0.14
- erythrocyte count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T3F8-F1 | alphafold | PREDICTED | 72.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T3F8.
Amino-acid sequence (832 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM63B?
The strongest Open Targets associations for TMEM63B are developmental and epileptic encephalopathy, neurodegenerative disease, Red cell distribution width, mean platelet volume and genetic disorder.
How long is the TMEM63B protein?
The Homo sapiens TMEM63B protein (UniProt Q5T3F8) is 832 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T3F8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T3F8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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