Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1)
Homo sapiens — UniProt Q5T3J3
Data last refreshed: (UniProt release unknown)
Key facts
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) is a protein from Homo sapiens identified by UniProt accession Q5T3J3, 769 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q5T3J3; gene symbol LRIF1.
- Organism: Homo sapiens.
- Length: 769 amino acids.
- Target class: Nuclear receptor.
- Top disease associations (Open Targets): facioscapulohumeral muscular dystrophy 4, digenic, facioscapulohumeral muscular dystrophy and non-Hodgkins lymphoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ligand-dependent nuclear receptor-interacting factor 1 |
|---|---|
| UniProt accession | Q5T3J3 |
| Gene | LRIF1 |
| Organism | Homo sapiens |
| Length | 769 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Nuclear receptor (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- facioscapulohumeral muscular dystrophy 4, digenic · score 0.33
- facioscapulohumeral muscular dystrophy · score 0.23
- non-Hodgkins lymphoma · score 0.13
- lymphocyte count · score 0.05
- platelet count · score 0.04
- eosinophil count · score 0.03
- Beta blocking agent use measurement · score 0.03
- intraocular pressure measurement · score 0.03
- schizophrenia · score 0.02
- acute lymphoblastic leukemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T3J3-F1 | alphafold | PREDICTED | 48.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T3J3.
Amino-acid sequence (769 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRIF1?
The strongest Open Targets associations for LRIF1 are facioscapulohumeral muscular dystrophy 4, digenic, facioscapulohumeral muscular dystrophy, non-Hodgkins lymphoma, lymphocyte count and platelet count.
How long is the LRIF1 protein?
The Homo sapiens LRIF1 protein (UniProt Q5T3J3) is 769 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T3J3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T3J3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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