Iron-sulfur cluster assembly factor IBA57, mitochondrial (IBA57)
Homo sapiens — UniProt Q5T440
Data last refreshed: (UniProt release unknown)
Key facts
Iron-sulfur cluster assembly factor IBA57, mitochondrial (IBA57) is a protein from Homo sapiens identified by UniProt accession Q5T440, 356 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q5T440; gene symbol IBA57.
- Organism: Homo sapiens.
- Length: 356 amino acids.
- Top disease associations (Open Targets): multiple mitochondrial dysfunctions syndrome 3, hereditary spastic paraplegia 74 and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Iron-sulfur cluster assembly factor IBA57, mitochondrial |
|---|---|
| UniProt accession | Q5T440 |
| Gene | IBA57 |
| Organism | Homo sapiens |
| Length | 356 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- multiple mitochondrial dysfunctions syndrome 3 · score 0.78
- hereditary spastic paraplegia 74 · score 0.69
- neurodegenerative disease · score 0.45
- genetic disorder · score 0.41
- mitochondrial disease · score 0.37
- Fatal multiple mitochondrial dysfunction syndrome · score 0.37
- Hypotonia-cerebral atrophy-hyperglycinemia syndrome · score 0.37
- birth weight · score 0.12
- Microcephaly · score 0.11
- lean body mass · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T440-F1 | alphafold | PREDICTED | 85.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T440.
Amino-acid sequence (356 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IBA57?
The strongest Open Targets associations for IBA57 are multiple mitochondrial dysfunctions syndrome 3, hereditary spastic paraplegia 74, neurodegenerative disease, genetic disorder and mitochondrial disease.
How long is the IBA57 protein?
The Homo sapiens IBA57 protein (UniProt Q5T440) is 356 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T440 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T440 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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