RNA-binding protein 20 (RBM20)
Homo sapiens — UniProt Q5T481
Data last refreshed: (UniProt release unknown)
Key facts
RNA-binding protein 20 (RBM20) is a protein from Homo sapiens identified by UniProt accession Q5T481, 1227 residues long. MolForge cross-references it against 0 known binders and 362 disease associations.
- UniProt accession: Q5T481; gene symbol RBM20.
- Organism: Homo sapiens.
- Length: 1227 amino acids.
- Top disease associations (Open Targets): dilated cardiomyopathy 1DD, dilated cardiomyopathy and Abnormality of the cardiovascular system.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA-binding protein 20 |
|---|---|
| UniProt accession | Q5T481 |
| Gene | RBM20 |
| Organism | Homo sapiens |
| Length | 1227 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (362)
Diseases linked to this target (Open Targets).
- dilated cardiomyopathy 1DD · score 0.82
- dilated cardiomyopathy · score 0.70
- Abnormality of the cardiovascular system · score 0.53
- cardiomyopathy · score 0.50
- left ventricular noncompaction · score 0.48
- Dilated cardiomyopathy · score 0.47
- familial dilated cardiomyopathy · score 0.45
- vital capacity · score 0.43
- electrocardiography · score 0.42
- dilated cardiomyopathy 1A · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T481-F1 | alphafold | PREDICTED | 48.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T481.
Amino-acid sequence (1227 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RBM20?
The strongest Open Targets associations for RBM20 are dilated cardiomyopathy 1DD, dilated cardiomyopathy, Abnormality of the cardiovascular system, cardiomyopathy and left ventricular noncompaction.
How long is the RBM20 protein?
The Homo sapiens RBM20 protein (UniProt Q5T481) is 1227 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T481 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T481 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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