Protrudin (ZFYVE27)
Homo sapiens — UniProt Q5T4F4
Data last refreshed: (UniProt release unknown)
Key facts
Protrudin (ZFYVE27) is a protein from Homo sapiens identified by UniProt accession Q5T4F4, 411 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q5T4F4; gene symbol ZFYVE27.
- Organism: Homo sapiens.
- Length: 411 amino acids.
- Top disease associations (Open Targets): hereditary spastic paraplegia 33, Spastic paraplegia and temporal lobe epilepsy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protrudin |
|---|---|
| UniProt accession | Q5T4F4 |
| Gene | ZFYVE27 |
| Organism | Homo sapiens |
| Length | 411 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- hereditary spastic paraplegia 33 · score 0.42
- Spastic paraplegia · score 0.19
- temporal lobe epilepsy · score 0.03
- hereditary spastic paraplegia · score 0.03
- alpha-linolenic acid measurement · score 0.02
- Systemic lupus erythematosus · score 0.02
- cancer · score 0.02
- axial length measurement · score 0.01
- autosomal dominant complex spastic paraplegia · score 0.01
- post-traumatic stress disorder · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T4F4-F1 | alphafold | PREDICTED | 70.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T4F4.
Amino-acid sequence (411 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZFYVE27?
The strongest Open Targets associations for ZFYVE27 are hereditary spastic paraplegia 33, Spastic paraplegia, temporal lobe epilepsy, hereditary spastic paraplegia and alpha-linolenic acid measurement.
How long is the ZFYVE27 protein?
The Homo sapiens ZFYVE27 protein (UniProt Q5T4F4) is 411 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T4F4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T4F4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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