Secreted frizzled-related protein 5 (SFRP5)
Homo sapiens — UniProt Q5T4F7
Data last refreshed: (UniProt release unknown)
Key facts
Secreted frizzled-related protein 5 (SFRP5) is a protein from Homo sapiens identified by UniProt accession Q5T4F7, 317 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.
- UniProt accession: Q5T4F7; gene symbol SFRP5.
- Organism: Homo sapiens.
- Length: 317 amino acids.
- Top disease associations (Open Targets): alpha-linolenic acid measurement, non-alcoholic fatty liver disease and myocardial infarction.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Secreted frizzled-related protein 5 |
|---|---|
| UniProt accession | Q5T4F7 |
| Gene | SFRP5 |
| Organism | Homo sapiens |
| Length | 317 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (163)
Diseases linked to this target (Open Targets).
- alpha-linolenic acid measurement · score 0.14
- non-alcoholic fatty liver disease · score 0.09
- myocardial infarction · score 0.08
- chronic kidney disease · score 0.08
- oral squamous cell carcinoma · score 0.08
- hepatocellular carcinoma · score 0.08
- melanoma · score 0.07
- Vitiligo · score 0.07
- non-alcoholic steatohepatitis · score 0.07
- type 2 diabetes mellitus · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T4F7-F1 | alphafold | PREDICTED | 81.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T4F7.
Amino-acid sequence (317 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SFRP5?
The strongest Open Targets associations for SFRP5 are alpha-linolenic acid measurement, non-alcoholic fatty liver disease, myocardial infarction, chronic kidney disease and oral squamous cell carcinoma.
How long is the SFRP5 protein?
The Homo sapiens SFRP5 protein (UniProt Q5T4F7) is 317 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T4F7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T4F7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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