Transmembrane protein 170B (TMEM170B)
Homo sapiens — UniProt Q5T4T1
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 170B (TMEM170B) is a protein from Homo sapiens identified by UniProt accession Q5T4T1, 132 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q5T4T1; gene symbol TMEM170B.
- Organism: Homo sapiens.
- Length: 132 amino acids.
- Top disease associations (Open Targets): mean platelet volume, platelet count and cognitive function measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 170B |
|---|---|
| UniProt accession | Q5T4T1 |
| Gene | TMEM170B |
| Organism | Homo sapiens |
| Length | 132 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.50
- platelet count · score 0.47
- cognitive function measurement · score 0.34
- diastolic blood pressure · score 0.34
- chronotype measurement · score 0.33
- intelligence · score 0.33
- systolic blood pressure · score 0.29
- hair color · score 0.23
- cutaneous melanoma · score 0.23
- balding measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T4T1-F1 | alphafold | PREDICTED | 88.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T4T1.
Amino-acid sequence (132 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM170B?
The strongest Open Targets associations for TMEM170B are mean platelet volume, platelet count, cognitive function measurement, diastolic blood pressure and chronotype measurement.
How long is the TMEM170B protein?
The Homo sapiens TMEM170B protein (UniProt Q5T4T1) is 132 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T4T1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T4T1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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