Cilia- and flagella-associated protein 276 (CFAP276)
Homo sapiens — UniProt Q5T5A4
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 276 (CFAP276) is a protein from Homo sapiens identified by UniProt accession Q5T5A4, 169 residues long. MolForge cross-references it against 0 known binders and 251 disease associations.
- UniProt accession: Q5T5A4; gene symbol CFAP276.
- Organism: Homo sapiens.
- Length: 169 amino acids.
- Top disease associations (Open Targets): alkaline phosphatase measurement, alcohol-related disorders and Charcot-Marie-Tooth disease type 2B1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 276 |
|---|---|
| UniProt accession | Q5T5A4 |
| Gene | CFAP276 |
| Organism | Homo sapiens |
| Length | 169 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (251)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.25
- alcohol-related disorders · score 0.20
- Charcot-Marie-Tooth disease type 2B1 · score 0.07
- Charcot-Marie-Tooth disease type 4F · score 0.07
- Charcot-Marie-Tooth disease type 1G · score 0.07
- Charcot-Marie-Tooth disease type 1A · score 0.07
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness · score 0.07
- Charcot-Marie-Tooth disease type 1C · score 0.07
- Charcot-Marie-Tooth disease X-linked dominant 1 · score 0.07
- chronic inflammatory demyelinating polyneuropathy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T5A4-F1 | alphafold | PREDICTED | 67.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T5A4.
Amino-acid sequence (169 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP276?
The strongest Open Targets associations for CFAP276 are alkaline phosphatase measurement, alcohol-related disorders, Charcot-Marie-Tooth disease type 2B1, Charcot-Marie-Tooth disease type 4F and Charcot-Marie-Tooth disease type 1G.
How long is the CFAP276 protein?
The Homo sapiens CFAP276 protein (UniProt Q5T5A4) is 169 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T5A4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T5A4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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