Syntaxin-binding protein 5 (STXBP5)
Homo sapiens — UniProt Q5T5C0
Data last refreshed: (UniProt release unknown)
Key facts
Syntaxin-binding protein 5 (STXBP5) is a protein from Homo sapiens identified by UniProt accession Q5T5C0, 1151 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q5T5C0; gene symbol STXBP5.
- Organism: Homo sapiens.
- Length: 1151 amino acids.
- Top disease associations (Open Targets): neutrophil count, mean platelet volume and von Willebrand factor measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Syntaxin-binding protein 5 |
|---|---|
| UniProt accession | Q5T5C0 |
| Gene | STXBP5 |
| Organism | Homo sapiens |
| Length | 1151 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.44
- mean platelet volume · score 0.41
- von Willebrand factor measurement · score 0.41
- leukocyte count · score 0.40
- systolic blood pressure · score 0.40
- monocyte count · score 0.39
- myeloid white cell count · score 0.36
- venous thromboembolism · score 0.35
- platelet count · score 0.35
- lymphocyte percentage of leukocytes · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T5C0-F1 | alphafold | PREDICTED | 78.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T5C0.
Amino-acid sequence (1151 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with STXBP5?
The strongest Open Targets associations for STXBP5 are neutrophil count, mean platelet volume, von Willebrand factor measurement, leukocyte count and systolic blood pressure.
How long is the STXBP5 protein?
The Homo sapiens STXBP5 protein (UniProt Q5T5C0) is 1151 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T5C0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T5C0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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