Sickle tail protein homolog (KIAA1217)

Homo sapiens — UniProt Q5T5P2

Gene: KIAA1217Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Sickle tail protein homolog (KIAA1217) is a protein from Homo sapiens identified by UniProt accession Q5T5P2, 1943 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

UniProt accession: Q5T5P2; gene symbol KIAA1217.
Organism: Homo sapiens.
Length: 1943 amino acids.
Top disease associations (Open Targets): body weight, self reported educational attainment and lobe attachment.
3D structure: AlphaFold model available.

Target properties

Protein name	Sickle tail protein homolog
UniProt accession	Q5T5P2
Gene	KIAA1217
Organism	Homo sapiens
Length	1943 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

body weight · score 0.35
self reported educational attainment · score 0.33
lobe attachment · score 0.33
hip bone size · score 0.30
body mass index · score 0.29
mathematical ability · score 0.28
cystatin C measurement · score 0.28
adolescent idiopathic scoliosis · score 0.25
systolic blood pressure · score 0.25
triglyceride measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T5P2-F1	alphafold	PREDICTED	46.20	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T5P2.

Amino-acid sequence (1943 residues)

MEENESQKCE PCLPYSADRR QMQEQGKGNL HVTSPEDAEC RRTKERLSNG NSRGSVSKSS RNIPRRHTLG GPRSSKEILG MQTSEMDRKR EAFLEHLKQK YPHHASAIMG HQERLRDQTR SPKLSHSPQP PSLGDPVEHL SETSADSLEA MSEGDAPTPF SRGSRTRASL PVVRSTNQTK ERSLGVLYLQ YGDETKQLRM PNEITSADTI RALFVSAFPQ QLTMKMLESP SVAIYIKDES RNVYYELNDV RNIQDRSLLK VYNKDPAHAF NHTPKTMNGD MRMQRELVYA RGDGPGAPRP GSTAHPPHAI PNSPPSTPVP HSMPPSPSRI PYGGTRSMVV PGNATIPRDR ISSLPVSRPI SPSPSAILER RDVKPDEDMS GKNIAMYRNE GFYADPYLYH EGRMSIASSH GGHPLDVPDH IIAYHRTAIR SASAYCNPSM QAEMHMEQSL YRQKSRKYPD SHLPTLGSKT PPASPHRVSD LRMIDMHAHY NAHGPPHTMQ PDRASPSRQA FKKEPGTLVY IEKPRSAAGL SSLVDLGPPL MEKQVFAYST ATIPKDRETR ERMQAMEKQI ASLTGLVQSA LFKGPITSYS KDASSEKMMK TTANRNHTDS AGTPHVSGGK MLSALESTVP PSQPPPVGTS AIHMSLLEMR RSVAELRLQL QQMRQLQLQN QELLRAMMKK AELEISGKVM ETMKRLEDPV QRQRVLVEQE RQKYLHEEEK IVKKLCELED FVEDLKKDST AASRLVTLKD VEDGAFLLRQ VGEAVATLKG EFPTLQNKMR AILRIEVEAV RFLKEEPHKL DSLLKRVRSM TDVLTMLRRH VTDGLLKGTD AAQAAQYMAM EKATAAEVLK SQEEAAHTSG QPFHSTGAPG DAKSEVVPLS GMMVRHAQSS PVVIQPSQHS VALLNPAQNL PHVASSPAVP QEATSTLQMS QAPQSPQIPM NGSAMQSLFI EEIHSVSAKN RAVSIEKAEK KWEEKRQNLD HYNGKEFEKL LEEAQANIMK SIPNLEMPPA TGPLPRGDAP VDKVELSEDS PNSEQDLEKL GGKSPPPPPP PPRRSYLPGS GLTTTRSGDV VYTGRKENIT AKASSEDAGP SPQTRATKYP AEEPASAWTP SPPPVTTSSS KDEEEEEEEG DKIMAELQAF QKCSFMDVNS NSHAEPSRAD SHVKDTRSGA TVPPKEKKNL EFFHEDVRKS DVEYENGPQM EFQKVTTGAV RPSDPPKWER GMENSISDAS RTSEYKTEII MKENSISNMS LLRDSRNYSQ ETVPKASFGF SGISPLEDEI NKGSKISGLQ YSIPDTENQT LNYGKTKEME KQNTDKCHVS SHTRLTESSV HDFKTEDQEV ITTDFGQVVL RPKEARHANV NPNEDGESSS SSPTEENAAT DNIAFMITET TVQVLSSGEV HDIVSQKGED IQTVNIDARK EMTPRQEGTD NEDPVVCLDK KPVIIIFDEP MDIRSAYKRL STIFEECDEE LERMMMEEKI EEEEEEENGD SVVQNNNTSQ MSHKKVAPGN LRTGQQVETK SQPHSLATET RNPGGQEMNR TELNKFSHVD SPNSECKGED ATDDQFESPK KKFKFKFPKK QLAALTQAIR TGTKTGKKTL QVVVYEEEEE DGTLKQHKEA KRFEIARSQP EDTPENTVRR QEQPSIESTS PISRTDEIRK NTYRTLDSLE QTIKQLENTI SEMSPKALVD TSCSSNRDSV ASSSHIAQEA SPRPLLVPDE GPTALEPPTS IPSASRKGSS GAPQTSRMPV PMSAKNRPGT LDKPGKQSKL QDPRQYRQAN GSAKKSGGDF KPTSPSLPAS KIPALSPSSG KSSSLPSSSG DSSNLPNPPA TKPSIASNPL SPQTGPPAHS ASLIPSVSNG SLKFQSLTHT GKGHHLSFSP QSQNGRAPPP LSFSSSPPSP ASSVSLNQGA KGTRTIHTPS LTSYKAQNGS SSKATPSTAK ETS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with KIAA1217?

The strongest Open Targets associations for KIAA1217 are body weight, self reported educational attainment, lobe attachment, hip bone size and body mass index.

How long is the KIAA1217 protein?

The Homo sapiens KIAA1217 protein (UniProt Q5T5P2) is 1943 amino acids long.

Browse: Targets: K · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q5T5P2 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q5T5P2 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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