Coiled-coil domain-containing protein 183 (CCDC183)
Homo sapiens — UniProt Q5T5S1
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil domain-containing protein 183 (CCDC183) is a protein from Homo sapiens identified by UniProt accession Q5T5S1, 534 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.
- UniProt accession: Q5T5S1; gene symbol CCDC183.
- Organism: Homo sapiens.
- Length: 534 amino acids.
- Top disease associations (Open Targets): essential tremor, azoospermia and breast cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil domain-containing protein 183 |
|---|---|
| UniProt accession | Q5T5S1 |
| Gene | CCDC183 |
| Organism | Homo sapiens |
| Length | 534 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (135)
Diseases linked to this target (Open Targets).
- essential tremor · score 0.26
- azoospermia · score 0.10
- breast cancer · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- hepatocellular carcinoma · score 0.08
- partial chromosome Y deletion · score 0.07
- congenital bilateral absence of vas deferens · score 0.06
- spinocerebellar ataxia type 32 · score 0.06
- spermatogenic failure 65 · score 0.06
- spermatogenic failure 56 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T5S1-F1 | alphafold | PREDICTED | 82.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T5S1.
Amino-acid sequence (534 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCDC183?
The strongest Open Targets associations for CCDC183 are essential tremor, azoospermia, breast cancer, male infertility with teratozoospermia due to single gene mutation and hepatocellular carcinoma.
How long is the CCDC183 protein?
The Homo sapiens CCDC183 protein (UniProt Q5T5S1) is 534 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T5S1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T5S1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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