Rho GTPase-activating protein 21 (ARHGAP21)

Homo sapiens — UniProt Q5T5U3

Gene: ARHGAP21Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Rho GTPase-activating protein 21 (ARHGAP21) is a protein from Homo sapiens identified by UniProt accession Q5T5U3, 1958 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.

UniProt accession: Q5T5U3; gene symbol ARHGAP21.
Organism: Homo sapiens.
Length: 1958 amino acids.
Top disease associations (Open Targets): neurodegenerative disease, lean body mass and Red cell distribution width.
3D structure: AlphaFold model available.

Target properties

Protein name	Rho GTPase-activating protein 21
UniProt accession	Q5T5U3
Gene	ARHGAP21
Organism	Homo sapiens
Length	1958 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (174)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.44
lean body mass · score 0.40
Red cell distribution width · score 0.36
mean corpuscular volume · score 0.35
appendicular lean mass · score 0.34
mean corpuscular hemoglobin · score 0.33
fat body mass · score 0.33
mean corpuscular hemoglobin concentration · score 0.33
cortical thickness · score 0.30
mean reticulocyte volume · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T5U3-F1	alphafold	PREDICTED	44.42	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T5U3.

Amino-acid sequence (1958 residues)

MMATRRTGLS EGDGDKLKAC EVSKNKDGKE QSETVSLSED ETFSWPGPKT VTLKRTSQGF GFTLRHFIVY PPESAIQFSY KDEENGNRGG KQRNRLEPMD TIFVKQVKEG GPAFEAGLCT GDRIIKVNGE SVIGKTYSQV IALIQNSDTT LELSVMPKDE DILQVLQFTK DVTALAYSQD AYLKGNEAYS GNARNIPEPP PICYPWLPSA PSAMAQPVEI SPPDSSLSKQ QTSTPVLTQP GRAYRMEIQV PPSPTDVAKS NTAVCVCNES VRTVIVPSEK VVDLLSNRNN HTGPSHRTEE VRYGVSEQTS LKTVSRTTSP PLSIPTTHLI HQPAGSRSLE PSGILLKSGN YSGHSDGISS SRSQAVEAPS VSVNHYSPNS HQHIDWKNYK TYKEYIDNRR LHIGCRTIQE RLDSLRAASQ STTDYNQVVP NRTTLQGRRR STSHDRVPQS VQIRQRSVSQ ERLEDSVLMK YCPRSASQGA LTSPSVSFSN HRTRSWDYIE GQDETLENVN SGTPIPDSNG EKKQTYKWSG FTEQDDRRGI CERPRQQEIH KSFRGSNFTV APSVVNSDNR RMSGRGVGSV SQFKKIPPDL KTLQSNRNFQ TTCGMSLPRG ISQDRSPLVK VRSNSLKAPS THVTKPSFSQ KSFVSIKDQR PVNHLHQNSL LNQQTWVRTD SAPDQQVETG KSPSLSGASA KPAPQSSENA GTSDLELPVS QRNQDLSLQE AETEQSDTLD NKEAVILREK PPSGRQTPQP LRHQSYILAV NDQETGSDTT CWLPNDARRE VHIKRMEERK ASSTSPPGDS LASIPFIDEP TSPSIDHDIA HIPASAVISA STSQVPSIAT VPPCLTTSAP LIRRQLSHDH ESVGPPSLDA QPNSKTERSK SYDEGLDDYR EDAKLSFKHV SSLKGIKIAD SQKSSEDSGS RKDSSSEVFS DAAKEGWLHF RPLVTDKGKR VGGSIRPWKQ MYVVLRGHSL YLYKDKREQT TPSEEEQPIS VNACLIDISY SETKRKNVFR LTTSDCECLF QAEDRDDMLA WIKTIQESSN LNEEDTGVTN RDLISRRIKE YNNLMSKAEQ LPKTPRQSLS IRQTLLGAKS EPKTQSPHSP KEESERKLLS KDDTSPPKDK GTWRKGIPSI MRKTFEKKPT ATGTFGVRLD DCPPAHTNRY IPLIVDICCK LVEERGLEYT GIYRVPGNNA AISSMQEELN KGMADIDIQD DKWRDLNVIS SLLKSFFRKL PEPLFTNDKY ADFIEANRKE DPLDRLKTLK RLIHDLPEHH YETLKFLSAH LKTVAENSEK NKMEPRNLAI VFGPTLVRTS EDNMTHMVTH MPDQYKIVET LIQHHDWFFT EEGAEEPLTT VQEESTVDSQ PVPNIDHLLT NIGRTGVSPG DVSDSATSDS TKSKGSWGSG KDQYSRELLV SSIFAAASRK RKKPKEKAQP SSSEDELDNV FFKKENVEQC HNDTKEESKK ESETLGRKQK IIIAKENSTR KDPSTTKDEK ISLGKESTPS EEPSPPHNSK HNKSPTLSCR FAILKESPRS LLAQKSSHLE ETGSDSGTLL STSSQASLAR FSMKKSTSPE TKHSEFLANV STITSDYSTT SSATYLTSLD SSRLSPEVQS VAESKGDEAD DERSELISEG RPVETDSESE FPVFPTALTS ERLFRGKLQE VTKSSRRNSE GSELSCTEGS LTSSLDSRRQ LFSSHKLIEC DTLSRKKSAR FKSDSGSLGD AKNEKEAPSL TKVFDVMKKG KSTGSLLTPT RGESEKQEPT WKTKIADRLK LRPRAPADDM FGVGNHKVNA ETAKRKSIRR RHTLGGHRDA TEISVLNFWK VHEQSGERES ELSAVNRLKP KCSAQDLSIS DWLARERLRT STSDLSRGEI GDPQTENPST REIATTDTPL SLHCNTGSSS STLASTNRPL LSIPPQSPDQ INGESFQNVS KNASSAANAQ PHKLSETPGS KAEFHPCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with ARHGAP21?

The strongest Open Targets associations for ARHGAP21 are neurodegenerative disease, lean body mass, Red cell distribution width, mean corpuscular volume and appendicular lean mass.

How long is the ARHGAP21 protein?

The Homo sapiens ARHGAP21 protein (UniProt Q5T5U3) is 1958 amino acids long.

Browse: Targets: A · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q5T5U3 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q5T5U3 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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