Cilia- and flagella-associated protein 58 (CFAP58)
Homo sapiens — UniProt Q5T655
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 58 (CFAP58) is a protein from Homo sapiens identified by UniProt accession Q5T655, 872 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q5T655; gene symbol CFAP58.
- Organism: Homo sapiens.
- Length: 872 amino acids.
- Top disease associations (Open Targets): spermatogenic failure 49, cognitive function measurement and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 58 |
|---|---|
| UniProt accession | Q5T655 |
| Gene | CFAP58 |
| Organism | Homo sapiens |
| Length | 872 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- spermatogenic failure 49 · score 0.66
- cognitive function measurement · score 0.33
- mathematical ability · score 0.30
- Agents acting on the renin-angiotensin system use measurement · score 0.25
- diastolic blood pressure · score 0.20
- mean platelet volume · score 0.19
- self reported educational attainment · score 0.15
- protein measurement · score 0.15
- cardiovascular disease · score 0.15
- azoospermia · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T655-F1 | alphafold | PREDICTED | 79.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T655.
Amino-acid sequence (872 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP58?
The strongest Open Targets associations for CFAP58 are spermatogenic failure 49, cognitive function measurement, mathematical ability, Agents acting on the renin-angiotensin system use measurement and diastolic blood pressure.
How long is the CFAP58 protein?
The Homo sapiens CFAP58 protein (UniProt Q5T655) is 872 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T655 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T655 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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