DDB1- and CUL4-associated factor 12 (DCAF12)
Homo sapiens — UniProt Q5T6F0
Data last refreshed: (UniProt release unknown)
Key facts
DDB1- and CUL4-associated factor 12 (DCAF12) is a protein from Homo sapiens identified by UniProt accession Q5T6F0, 453 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.
- UniProt accession: Q5T6F0; gene symbol DCAF12.
- Organism: Homo sapiens.
- Length: 453 amino acids.
- Top disease associations (Open Targets): monocyte count, mean corpuscular volume and testosterone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DDB1- and CUL4-associated factor 12 |
|---|---|
| UniProt accession | Q5T6F0 |
| Gene | DCAF12 |
| Organism | Homo sapiens |
| Length | 453 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.51
- mean corpuscular volume · score 0.50
- testosterone measurement · score 0.50
- alkaline phosphatase measurement · score 0.48
- mean corpuscular hemoglobin · score 0.47
- serum alanine aminotransferase measurement · score 0.47
- neutrophil percentage of leukocytes · score 0.46
- mean corpuscular hemoglobin concentration · score 0.45
- lymphocyte count · score 0.43
- monocyte percentage of leukocytes · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T6F0-F1 | alphafold | PREDICTED | 84.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T6F0.
Amino-acid sequence (453 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCAF12?
The strongest Open Targets associations for DCAF12 are monocyte count, mean corpuscular volume, testosterone measurement, alkaline phosphatase measurement and mean corpuscular hemoglobin.
How long is the DCAF12 protein?
The Homo sapiens DCAF12 protein (UniProt Q5T6F0) is 453 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T6F0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T6F0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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