Endoplasmic reticulum membrane-associated RNA degradation protein (ERMARD)
Homo sapiens — UniProt Q5T6L9
Data last refreshed: (UniProt release unknown)
Key facts
Endoplasmic reticulum membrane-associated RNA degradation protein (ERMARD) is a protein from Homo sapiens identified by UniProt accession Q5T6L9, 678 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q5T6L9; gene symbol ERMARD.
- Organism: Homo sapiens.
- Length: 678 amino acids.
- Top disease associations (Open Targets): nodular neuronal heterotopia, periventricular nodular heterotopia and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Endoplasmic reticulum membrane-associated RNA degradation protein |
|---|---|
| UniProt accession | Q5T6L9 |
| Gene | ERMARD |
| Organism | Homo sapiens |
| Length | 678 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- nodular neuronal heterotopia · score 0.47
- periventricular nodular heterotopia · score 0.37
- neurodegenerative disease · score 0.33
- Seizure · score 0.11
- self reported educational attainment · score 0.09
- smoking status measurement · score 0.08
- monocyte count · score 0.07
- vital capacity · score 0.06
- reticulocyte count · score 0.04
- reticulocyte measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T6L9-F1 | alphafold | PREDICTED | 90.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T6L9.
Amino-acid sequence (678 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ERMARD?
The strongest Open Targets associations for ERMARD are nodular neuronal heterotopia, periventricular nodular heterotopia, neurodegenerative disease, Seizure and self reported educational attainment.
How long is the ERMARD protein?
The Homo sapiens ERMARD protein (UniProt Q5T6L9) is 678 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T6L9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T6L9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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