G-protein coupled receptor family C group 6 member A (GPRC6A)
Homo sapiens — UniProt Q5T6X5
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor family C group 6 member A (GPRC6A) is a protein from Homo sapiens identified by UniProt accession Q5T6X5, 926 residues long. MolForge cross-references it against 2 known binders and 186 disease associations.
- UniProt accession: Q5T6X5; gene symbol GPRC6A.
- Organism: Homo sapiens.
- Length: 926 amino acids.
- Approved drugs acting on it (DrugCentral): Arginine and Ornithine.
- Top disease associations (Open Targets): apolipoprotein A 1 measurement, diastolic blood pressure and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor family C group 6 member A |
|---|---|
| UniProt accession | Q5T6X5 |
| Gene | GPRC6A |
| Organism | Homo sapiens |
| Length | 926 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (186)
Diseases linked to this target (Open Targets).
- apolipoprotein A 1 measurement · score 0.28
- diastolic blood pressure · score 0.25
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.24
- ovarian cancer · score 0.21
- birth weight · score 0.19
- parental genotype effect measurement · score 0.19
- C-reactive protein measurement · score 0.19
- lung adenocarcinoma · score 0.18
- prostate carcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T6X5-F1 | alphafold | PREDICTED | 84.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T6X5.
Amino-acid sequence (926 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target GPRC6A?
DrugCentral lists 2 approved drugs whose mechanism of action is GPRC6A: Arginine and Ornithine.
Which diseases are associated with GPRC6A?
The strongest Open Targets associations for GPRC6A are apolipoprotein A 1 measurement, diastolic blood pressure, breast adenocarcinoma, glioblastoma multiforme and ovarian cancer.
How long is the GPRC6A protein?
The Homo sapiens GPRC6A protein (UniProt Q5T6X5) is 926 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T6X5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T6X5 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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