KN motif and ankyrin repeat domain-containing protein 4 (KANK4)
Homo sapiens — UniProt Q5T7N3
Data last refreshed: (UniProt release unknown)
Key facts
KN motif and ankyrin repeat domain-containing protein 4 (KANK4) is a protein from Homo sapiens identified by UniProt accession Q5T7N3, 995 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q5T7N3; gene symbol KANK4.
- Organism: Homo sapiens.
- Length: 995 amino acids.
- Top disease associations (Open Targets): blood protein measurement, Fuchs endothelial corneal dystrophy and nephrotic syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | KN motif and ankyrin repeat domain-containing protein 4 |
|---|---|
| UniProt accession | Q5T7N3 |
| Gene | KANK4 |
| Organism | Homo sapiens |
| Length | 995 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.38
- Fuchs endothelial corneal dystrophy · score 0.29
- nephrotic syndrome · score 0.26
- social interaction measurement · score 0.26
- neurodegenerative disease · score 0.15
- refractive error measurement · score 0.10
- corneal topography · score 0.09
- Keloid · score 0.07
- body height · score 0.02
- myeloid sarcoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T7N3-F1 | alphafold | PREDICTED | 56.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T7N3.
Amino-acid sequence (995 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KANK4?
The strongest Open Targets associations for KANK4 are blood protein measurement, Fuchs endothelial corneal dystrophy, nephrotic syndrome, social interaction measurement and neurodegenerative disease.
How long is the KANK4 protein?
The Homo sapiens KANK4 protein (UniProt Q5T7N3) is 995 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T7N3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T7N3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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