Synaptotagmin-6 (SYT6)

About Synaptotagmin-6

Synaptotagmin-6 (SYT6) is a protein from Homo sapiens identified by UniProt accession Q5T7P8, 510 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.

Target properties

Protein name	Synaptotagmin-6
UniProt accession	Q5T7P8
Gene	SYT6
Organism	Homo sapiens
Length	510 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (9)

Diseases linked to this target (Open Targets).

breast ductal adenocarcinoma · score 0.11
metabolite measurement · score 0.03
primary ovarian insufficiency · score 0.01
gonorrhea · score 0.01
uterine leiomyosarcoma · score 0.01
Down syndrome · score 0.00
schizophrenia · score 0.00
axial length measurement · score 0.00
Hyperlipidemia · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5T7P8-F1	alphafold	PREDICTED	73.23	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T7P8.

Amino-acid sequence (510 residues)

MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS AAGAGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN PPLEALQSPS FRGNMADKLK DPSTLGFLEA AVKISHTSPD IPAEVQMSVK EHIMRHTRLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAEQ PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD YETETLIVRI LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK DIQYATSESV DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY VKVSLLCDGR RLKKKKTTIK KNTLNPVYNE AIIFDIPPEN MDQVSLLISV MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN EMLAYPRKPI AHWHSLVEVK KSFKEGNPRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards