Metabotropic glycine receptor (GPR158)
Homo sapiens — UniProt Q5T848
Data last refreshed: (UniProt release unknown)
Key facts
Metabotropic glycine receptor (GPR158) is a protein from Homo sapiens identified by UniProt accession Q5T848, 1215 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: Q5T848; gene symbol GPR158.
- Organism: Homo sapiens.
- Length: 1215 amino acids.
- Top disease associations (Open Targets): diverticular disease, intraocular pressure measurement and verbal-numerical reasoning measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Metabotropic glycine receptor |
|---|---|
| UniProt accession | Q5T848 |
| Gene | GPR158 |
| Organism | Homo sapiens |
| Length | 1215 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- diverticular disease · score 0.39
- intraocular pressure measurement · score 0.34
- verbal-numerical reasoning measurement · score 0.30
- intelligence · score 0.29
- central corneal thickness · score 0.28
- diverticulitis · score 0.27
- Red cell distribution width · score 0.26
- intestinal disease · score 0.15
- response to vaccine · score 0.11
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T848-F1 | alphafold | PREDICTED | 58.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T848.
Amino-acid sequence (1215 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR158?
The strongest Open Targets associations for GPR158 are diverticular disease, intraocular pressure measurement, verbal-numerical reasoning measurement, intelligence and central corneal thickness.
How long is the GPR158 protein?
The Homo sapiens GPR158 protein (UniProt Q5T848) is 1215 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T848 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T848 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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