About DNA excision repair protein ERCC-6-like 2
DNA excision repair protein ERCC-6-like 2 (ERCC6L2) is a protein
from Homo sapiens identified by UniProt accession
Q5T890, 1561 residues long.
MolForge cross-references it against 0 known binders and
201 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (201)
Diseases linked to this target (Open Targets).
- pancytopenia-developmental delay syndrome · score 0.77
- body height · score 0.41
- alkaline phosphatase measurement · score 0.37
- neurodegenerative disease · score 0.37
- inherited acute myeloid leukemia · score 0.37
- lymphocyte count · score 0.37
- hereditary neoplastic syndrome · score 0.34
- Inherited cancer-predisposing syndrome · score 0.34
- PHF-tau measurement · score 0.30
- Thrombocytopenia · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q5T890.
Amino-acid sequence (1561 residues)
MQPGSAPPPG RMDPSAPQPR AETSGKDIWH PGERCLAPSP DNGKLCEASI KSITVDENGK SFAVVLYADF QERKIPLKQL QEVKFVKDCP RNLIFDDEDL EKPYFPNRKF PSSSVAFKLS DNGDSIPYTI NRYLRDYQRE GTRFLYGHYI HGGGCILGDD MGLGKTVQVI SFLAAVLHKK GTREDIENNM PEFLLRSMKK EPLSSTAKKM FLIVAPLSVL YNWKDELDTW GYFRVTVLHG NRKDNELIRV KQRKCEIALT TYETLRLCLD ELNSLEWSAV IVDEAHRIKN PKARVTEVMK ALKCNVRIGL TGTILQNNMK ELWCVMDWAV PGLLGSGTYF KKQFSDPVEH GQRHTATKRE LATGRKAMQR LAKKMSGWFL RRTKTLIKDQ LPKKEDRMVY CSLTDFQKAV YQTVLETEDV TLILQSSEPC TCRSGQKRRN CCYKTNSHGE TVKTLYLSYL TVLQKVANHV ALLQAASTSK QQETLIKRIC DQVFSRFPDF VQKSKDAAFE TLSDPKYSGK MKVLQQLLNH CRKNRDKVLL FSFSTKLLDV LQQYCMASGL DYRRLDGSTK SEERLKIVKE FNSTQDVNIC LVSTMAGGLG LNFVGANVVV LFDPTWNPAN DLQAIDRAYR IGQCRDVKVL RLISLGTVEE IMYLRQIYKQ QLHCVVVGSE NAKRYFEAVQ GSKEHQGELF GIHNLFKFRS QGSCLTKDIL EREGQVEAGI MTATTWLKEG PPAHKLEMPR QPDCQECRGT EQAAEPLAKE ACDLCSDFSD EEPVGATGIK TAKNKAPDSS KASSSPGQLT LLQCGFSKLL ETKCKAVEDS DGNTASDDES SDEQPTCLST EAKDAGCEKN QDSLGTSKHQ KLDNILNPKE KHIFYKSEKI LEQNISSKSD EKKIKNTDKH CILQNVTESE DSDVICPTQY TTERFPDNSI RFKPPLEGSE DSETEHTVKT RNNDNSRNTD DKRNGIISKK LSPENTTLKS ILKRKGTSDI SDESDDIEIS SKSRVRKRAS SLRFKRIKET KKELHNSPKT MNKTNQVYAA NEDHNSQFID DYSSSDESLS VSHFSFSKQS HRPRTIRDRT SFSSKLPSHN KKNSTFIPRK PMKCSNEKVV NQEQSYESMD KFLDGVQEVA YIHSNQNVIG SSKAENHMSR WAAHDVFELK QFSQLPANIA VCSSKTYKEK VDADTLPHTK KGQQPSEGSI SLPLYISNPV NQKKKKVYHT NQTTFIIGET PKGIRRKQFE EMASYFNSSS VNEFAKHITN ATSEERQKML RDFYASQYPE VKEFFVDSVS QFNNSSFEKG EQRTRKKSDK RESLIKPRLS DSETLSFKDS TNKISQVCSL KTYKRKSVKF QNHISYREEV FFNDAETKKS PVSSTQEIDS GKNSQASEDT VTSRSLNSES ETRERRLENT MKDQQDLTRT GISRKEPLLK LENKKIENPV LENTSVISLL GDTSILDDLF KSHGNSPTQL PKKVLSGPME KAKQRPKDFW DILNEQNDES LSKLTDLAVI ETLCEKAPLA APFKRREEPA TSLWKSNEKF LWKKFSPSDT DENATNTQST T
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