Acyl-CoA-binding domain-containing protein 5 (ACBD5)
Homo sapiens — UniProt Q5T8D3
Data last refreshed: (UniProt release unknown)
Key facts
Acyl-CoA-binding domain-containing protein 5 (ACBD5) is a protein from Homo sapiens identified by UniProt accession Q5T8D3, 534 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q5T8D3; gene symbol ACBD5.
- Organism: Homo sapiens.
- Length: 534 amino acids.
- Top disease associations (Open Targets): retinal dystrophy with leukodystrophy, acyl-CoA binding domain containing protein 5 deficiency and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Acyl-CoA-binding domain-containing protein 5 |
|---|---|
| UniProt accession | Q5T8D3 |
| Gene | ACBD5 |
| Organism | Homo sapiens |
| Length | 534 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- retinal dystrophy with leukodystrophy · score 0.67
- acyl-CoA binding domain containing protein 5 deficiency · score 0.60
- genetic disorder · score 0.19
- Thrombocytopenia · score 0.19
- cone-rod dystrophy · score 0.14
- Cone rod dystrophy · score 0.14
- late-onset Alzheimers disease · score 0.14
- scimitar anomaly, multiple cardiac malformations, and craniofacial and central nervous system abnormalities · score 0.12
- platelet count · score 0.06
- Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T8D3-F1 | alphafold | PREDICTED | 56.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T8D3.
Amino-acid sequence (534 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACBD5?
The strongest Open Targets associations for ACBD5 are retinal dystrophy with leukodystrophy, acyl-CoA binding domain containing protein 5 deficiency, genetic disorder, Thrombocytopenia and cone-rod dystrophy.
How long is the ACBD5 protein?
The Homo sapiens ACBD5 protein (UniProt Q5T8D3) is 534 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T8D3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T8D3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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